Key result
Chronic pacing tachycardia in dogs reduced systolic function (end-systolic pressure-volume relation slope 1.29 vs 2.71 mm Hg/ml, p<0.01) and increased energy efficiency compared to controls.
Population
15 dogs (7 in heart failure group, 8 in control group)
Comparison
Chronic ventricular pacing at 250 beats per… vs Unpaced control group
Design
Preclinical
Follow-up
26.3 +/- 2.9 days
Authors
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No immediate clinical implications; leaves open translation of efficiency gains to human systolic HF.
Absolute Event Rate: 1.29% vs 2.71%
p-value: p=<0.01
In a canine model of pacing-induced heart failure, hearts exhibited reduced contractility, dilatation, impaired contractile reserve, and increased efficiency of chemomechanical energy conversion.
Wolff et al. (1992) studied Experimental heart failure (n=15). Chronic pacing tachycardia vs. Unpaced control group was evaluated on Slope of the end-systolic pressure-volume relation (mm Hg/ml) (p=<0.01). Chronic pacing tachycardia in dogs reduced systolic function (end-systolic pressure-volume relation slope 1.29 vs 2.71 mm Hg/ml, p<0.01) and increased energy efficiency compared to controls.
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