Key result
Isoproterenol infusion significantly increased local regional work, force, myocardial O2 consumption, and cAMP in control and LVH dogs, but these responses were absent in pacing-induced heart failure.
Why the study?
Does beta-adrenoceptor stimulation with isoproterenol improve functional and metabolic responses in pacing-induced heart failure in hypertrophic dog hearts?
Population
15 anaesthetized open-chest dogs
Comparison
Isoproterenol infused into a coronary artery vs Responses compared across control, LVH, and LVH…
Design
Preclinical
Authors
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May indicate beta-adrenergic desensitization in advanced canine HF; leaves open relevance to human disease progression and therapy.
Does beta-adrenoceptor stimulation with isoproterenol improve functional and metabolic responses in pacing-induced heart failure in hypertrophic dog hearts?
The transition from hypertrophy to pacing-induced heart failure in dogs is associated with a loss of functional, metabolic, and cAMP responses to beta-adrenergic stimulation.
Huang et al. (2000) studied Left ventricular hypertrophy and pacing-induced heart failure (n=15). Isoproterenol vs. Control and LVH dogs was evaluated on Myocardial functional, O2 consumption, and cAMP responses to isoproterenol. Isoproterenol infusion significantly increased local regional work, force, myocardial O2 consumption, and cAMP in control and LVH dogs, but these responses were absent in pacing-induced heart failure.
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