Why the study?
Does propranolol or cardiac denervation improve neurohumoral profiles and neurochemical markers in dogs with pacing-induced heart failure?
Does propranolol or cardiac denervation improve neurohumoral profiles and neurochemical markers in dogs with pacing-induced heart failure?
In a canine model of pacing-induced heart failure, beta-blockade with propranolol did not modify neurohumoral or neurochemical responses, suggesting little direct influence on sympathetic vasomotor activity or neuronal function.
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Propranolol and denervation do not blunt sympathetic activation in this canine model; leaves open effects on neurohumoral profiles in clinical HF.
Levett et al. (1994) studied this question.
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