Why the study?
Does rapid ventricular pacing-induced heart failure alter myocardial norepinephrine uptake kinetics and beta-adrenoceptor density in dogs?
Population
Dogs subjected to rapid ventricular pacing to induce heart failure
Comparison
Rapid ventricular pacing at 225 beats/min for 8… vs Dogs paced at 100 beats/min for 8 weeks
Design
Preclinical
Follow-up
8 weeks
Authors
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No immediate clinical implications; extends mechanistic insights on NE uptake in experimental HF but leaves human relevance open.
Does rapid ventricular pacing-induced heart failure alter myocardial norepinephrine uptake kinetics and beta-adrenoceptor density in dogs?
In a canine model of pacing-induced heart failure, excess myocardial interstitial norepinephrine content due to depressed neuronal uptake contributes to beta-adrenoceptor downregulation.
Delehanty et al. (1994) studied this question.
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