Population
Dogs with heart failure induced by rapid ventricular pacing for 28 days and control dogs
Comparison
Intra-arterial boluses of norepinephrine before… vs Lung lobes from control dogs
Design
Preclinical
Follow-up
28 days
Authors
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Pulmonary vascular changes in this canine HF model are hypothesis-generating; leaves open relevance to human disease and clinical translation.
In a canine model of pacing-induced heart failure, pulmonary adaptations include functional changes in pulmonary hemodynamics and enhanced venous vascular reactivity to norepinephrine, without altering microvascular permeability.
Townsley et al. (1994) studied this question.
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