What question did this study set out to answer?

To assess baroreflex control of heart rate in response to hypertensive and hypotensive stimuli during the induction and reversal of severe congestive heart failure.

March 1, 1994Cardiovascular Research

Recovery of attenuated baroreflex sensitivity in conscious dogs after reversal of pacing induced heart failure

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Why the study?

Does cessation of pacing-induced heart failure improve baroreflex sensitivity in conscious dogs?

Population

6 conscious dogs with rapid ventricular pacing-induced severe congestive heart failure

Comparison

Cessation of pacing and allowing recovery for… vs Baseline and severe heart failure states

Design

Preclinical

Follow-up

4 weeks

Authors

EGEtienne A. GrimaCanadian Heart Research Centre GMGordon W. MoeHeart Failure & Transplant RHRichard J. HowardOrgan Recovery Systems (United States)

Discussion

Member takes

Implication

Rapid baroreflex recovery after pacing cessation suggests functional impairment in canine HF; hypothesis-generating for reversible autonomic dysfunction in patients.

Key Points

To assess baroreflex control of heart rate in response to hypertensive and hypotensive stimuli during the induction and reversal of severe congestive heart failure.
Studied six conscious dogs (N=6) paced to severe congestive heart failure and subsequently monitored during a four-week recovery period.
Assessed baroreflex sensitivity using the slope of the R-R interval to systolic blood pressure relationship during acute challenges with phenylephrine and nitroprusside.
Severe heart failure significantly blunted baroreflex sensitivity slopes from baseline values of 27.05 to 1.88 ms·mm Hg⁻¹ for phenylephrine and 17.1 to 4.21 ms·mm Hg⁻¹ for nitroprusside (both p < 0.05).
Baroreflex control recovered within 48 hours of pacing cessation and persisted through four weeks alongside normalized cardiac output and noradrenaline, despite sustained cardiac dilatation.

Structured PICO

Does cessation of pacing-induced heart failure improve baroreflex sensitivity in conscious dogs?

Population

6 conscious dogs with rapid ventricular pacing-induced severe congestive heart failure

Intervention

Cessation of pacing and allowing recovery for four weeks

Comparator

Baseline (control) and severe heart failure states (serial assessments)

Outcome

Baroreflex control of heart rate (baroreflex sensitivity) in response to acute hypertensive (phenylephrine) and hypotensive (nitroprusside) stimulisurrogate

In a canine model of pacing-induced heart failure, attenuated baroreflex sensitivity rapidly recovers upon cessation of pacing, suggesting functional rather than morphological impairment.

Cite This Study

Grima et al. (1994) studied this question.

synapsesocial.com/papers/6a86d577b688e10ffe82b164 https://doi.org/10.1093/cvr/28.3.384

Topics

Heart failure HFrEF treatment Echocardiography

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Implication

Rapid baroreflex recovery after pacing cessation suggests functional impairment in canine HF; hypothesis-generating for reversible autonomic dysfunction in patients.

Recovery of attenuated baroreflex sensitivity in conscious dogs after reversal of pacing induced heart failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Recovery of attenuated baroreflex sensitivity in conscious dogs after reversal of pacing induced heart failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider