Why the study?
What are the mechanisms underlying abnormal baroreflex control of circulation in experimental heart failure?
Population
Dogs with experimental chronic heart failure induced by continuous ventricular pacing for up to 6 weeks.
Comparison
Experimental manipulations including carotid… vs Normal dogs.
Design
Preclinical
Follow-up
up to 6 weeks (pacing duration)
Authors
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Implicates Na-K ATPase in experimental HF baroreceptor dysfunction; leaves open translation to human baroreflex therapies.
What are the mechanisms underlying abnormal baroreflex control of circulation in experimental heart failure?
In an experimental dog model of heart failure, depressed baroreflex sensitivity is mediated by alterations in arterial and cardiac receptor discharge, potentially involving augmented Na-K ATPase activity, rather than central regulation.
Zucker et al. (1991) studied this question.
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