Why the study?
How do arterial baroreceptor and cardiopulmonary reflexes control sympathetic outflow in human heart failure compared to normal subjects?
Population
Subjects with normal and impaired left ventricular systolic function (heart failure)
Comparison
Physiological testing including sodium… vs Control subjects with normal left ventricular…
Design
Review
Authors
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Supports differential cardiopulmonary reflex control in systolic dysfunction; leaves open whether baroreflex modulation improves heart failure outcomes.
How do arterial baroreceptor and cardiopulmonary reflexes control sympathetic outflow in human heart failure compared to normal subjects?
Human heart failure is characterized by a preserved, rapidly responsive arterial baroreflex and activation of a cardiac sympathoexcitatory reflex related to increased cardiopulmonary filling pressures.
John S. Floras (2001) studied this question.
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