Key result
Mild CHF linked to ~37% higher muscle sympathetic nerve activity versus healthy controls.
Why the study?
Baroreflex control of sympathetic activity is impaired in severe CHF, but it is unclear whether this impairment and sympathetic activation also occur in mild CHF.
Is baroreflex control of sympathetic activity impaired in patients with mild congestive heart failure compared to healthy controls?
Observational (n=53)
Is baroreflex control of sympathetic activity impaired in patients with mild congestive heart failure compared to healthy controls?
Absolute Event Rate: 64.4% vs 47.1%
p-value: p=< .05
Baroreflex control of sympathetic activity is already markedly impaired in mild congestive heart failure, which may drive the early sympathetic activation seen in the disease course.
No takes yet. Share an insight, caveat, or question.
May indicate early baroreflex impairment in mild HF; leaves open causal mechanisms and intervention targets.
Grassı et al. (1995) conducted an observational in Congestive heart failure (n=53). Mild congestive heart failure vs. Healthy control subjects was evaluated on Muscle sympathetic nerve activity (MSNA, bursts per 100 heart beats) (p=< .05). Mild congestive heart failure is associated with significantly increased muscle sympathetic nerve activity compared to healthy controls (64.4 vs 47.1 bursts per 100 heart beats, P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: