Carotid sinus baroreceptor reflex in dogs with experimental heart failure.
Why the study?
Does pacing-induced heart failure alter carotid sinus baroreceptor reflex sensitivity and end-organ responsiveness in dogs?
Population
Dogs with pacing-induced experimental heart failure and normal dogs
Comparison
Carotid sinus pressurization and electrical… vs Normal dogs
Design
Preclinical
Authors
Discussion
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Implication
Depressed pressor response in pacing-induced canine HF implicates end-organ impairment; leaves open translation to human baroreflex dysfunction.
Structured PICO
Does pacing-induced heart failure alter carotid sinus baroreceptor reflex sensitivity and end-organ responsiveness in dogs?
P
Population
Dogs with pacing-induced experimental heart failure and normal dogs
I
Intervention
Carotid sinus pressurization and electrical stimulation of the carotid sinus nerve
C
Comparator
Normal dogs
O
Outcome
Carotid sinus baroreceptor reflex sensitivity (measured by mean arterial pressure and renal sympathetic nerve activity)surrogate
The depressed carotid sinus baroreceptor reflex in heart failure may be related to poor end-organ responses rather than solely depressed baroreceptor responsiveness.
Cite This Study
Wang et al. (1991) studied this question.