October 1, 1993AJP Heart and Circulatory Physiology
Influence of vagotomy on the baroreflex sensitivity in anesthetized dogs with experimental heart failure
Why the study?
Does bilateral vagotomy alter baroreflex sensitivity in dogs with pacing-induced heart failure?
Population
Anesthetized dogs with pacing-induced heart failure (paced at 250 beats/min) and sham controls
Comparison
Bilateral vagotomy vs Intact state (before vagotomy) and sham controls
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Does not implicate vagal afferents; leaves open alternative mechanisms of baroreflex depression in heart failure models.
Key Points
- This study aims to assess how vagotomy affects baroreflex sensitivity in dogs with induced heart failure.
- Cardiac pacing at 250 beats/min until heart failure develops in dogs
- Comparison of baroreflex gain in vagotomized and intact states
- Measurement of MAP and renal sympathetic nerve activity during carotid sinus pressure changes
- Before vagotomy, peak MAP response was significantly lower in heart failure dogs (-18.3% vs. -37.0%, P < 0.001)
- CSP-MAP curves were depressed in heart failure dogs with no frequency-RSNA alterations
- No significant changes in baroreflex gain after vagotomy in both sham and heart failure groups
Structured PICO
Does bilateral vagotomy alter baroreflex sensitivity in dogs with pacing-induced heart failure?
P
Population
Anesthetized dogs with pacing-induced heart failure (paced at 250 beats/min) and sham controls
I
Intervention
Bilateral vagotomy
C
Comparator
Intact state (before vagotomy) and sham controls
O
Outcome
Baroreflex sensitivity (Mean arterial pressure and renal sympathetic nerve activity responses to carotid sinus pressurization and carotid sinus nerve stimulation)surrogate
Vagotomy does not significantly alter baroreflex gain responses in dogs with pacing-induced heart failure, suggesting the depressed baroreflex sensitivity is not primarily mediated by vagal afferents.
Cite This Study
Wang et al. (1993) studied this question.