April 1, 1991AJP Heart and Circulatory Physiology
Postexcitatory depression of baroreceptors in dogs with experimental heart failure
Population
14 dogs
Comparison
Perfusion of the isolated carotid sinus with… vs Normal dogs; baseline without ouabain
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for baroreceptor Na+-K+-ATPase in HF; should not yet influence clinical management.
Structured PICO
P
Population
14 dogs (8 normal and 6 with experimental heart failure induced by ventricular pacing at 250 beats/min for approximately 5 weeks)
I
Intervention
Perfusion of the isolated carotid sinus with very low doses of ouabain
C
Comparator
Normal dogs; baseline without ouabain
O
Outcome
Duration of postexcitatory depression (PED) of carotid sinus baroreceptorssurrogate
Experimental heart failure in dogs is associated with prolonged postexcitatory depression of baroreceptors, which is attenuated by ouabain, suggesting increased Na+-K+-ATPase activity in baroreceptor endings.
Cite This Study
Wang et al. (1991) studied this question.