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July 1, 1996AJP Heart and Circulatory Physiology

Pulmonary vascular response to angiotensin II in canine pacing-induced heart failure

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Why the study?

Does angiotensin II affect pulmonary vascular resistance and microvascular permeability differently in canine pacing-induced heart failure compared to controls?

Population

Isolated, blood-perfused, ventilated canine lung lobes from control animals and animals with pacing-induced…

Comparison

Intra-arterial boluses of angiotensin II vs Control canine lung lobes and baseline…

Design

Preclinical

Authors

BRBeverly J. RoyEmory UniversityVPV. H. PittsUniversity of South AlabamaMTMary I. TownsleyUniversity of South Alabama

Discussion

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Overview

Caution against clinical extrapolation from canine models; leaves open in vivo relevance to human HF-related pulmonary resistance.

Structured PICO

Does angiotensin II affect pulmonary vascular resistance and microvascular permeability differently in canine pacing-induced heart failure compared to controls?

P
Population
Isolated, blood-perfused, ventilated canine lung lobes from control animals (n = 40) and animals with pacing-induced heart failure (n = 15, paced at 245 beats/min for 30.6 +/- 0.9 days until LV shortening fraction decreased by 56%).
I
Intervention
Intra-arterial boluses of angiotensin II (1-10 micrograms)
C
Comparator
Control canine lung lobes and baseline measurements
O
Outcome
Pulmonary vascular resistance (arterial and venous) and microvascular permeability (capillary filtration coefficient)surrogate

Angiotensin II enhances pulmonary vasoconstriction in pacing-induced heart failure, but this effect is abolished at high venous pressures, suggesting it may not contribute to increased pulmonary vascular resistance in vivo.

Cite This Study

Roy et al. (1996) studied this question.

synapsesocial.com/papers/6a7b6f07684c0941cf3265aehttps://doi.org/10.1152/ajpheart.1996.271.1.h222
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ablation of lung endothelial injury after pacing-induced heart failure is related to alterations in Ca<sup>2+</sup>signaling1998 · 14 citations
  2. 2Altered pulmonary microvascular reactivity to norepinephrine in canine pacing-induced heart failure.1994 · 22 citations
  3. 3Influence of angiotensin on the early progression of heart failure2000 · 24 citations
  4. 4Altered Ventricular and Myocyte Response to Angiotensin II in Pacing-Induced Heart Failure1996 · 99 citations
  5. 5ACE inhibitors in HF restore canine pulmonary endothelial function and ANG II vasoconstriction1999 · 9 citations