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September 1, 1998AJP Heart and Circulatory Physiology

Ablation of lung endothelial injury after pacing-induced heart failure is related to alterations in Ca2+signaling

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Population

Isolated blood-perfused canine lung lobes from control dogs and dogs with pacing-induced heart failure.

Comparison

Thapsigargin or Ca2+ ionophore A-23187. vs Control lobes vs. paced (heart failure) lobes.

Design

Preclinical

Authors

CIClaire L. IveyUniversity of South AlabamaBRBeverly J. RoyEmory UniversityMTMary I. TownsleyUniversity of South Alabama

Discussion

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Implication

Altered endothelial Ca2+ handling may attenuate permeability in experimental HF; leaves open translation to human pulmonary edema.

Structured PICO

P
Population
Isolated blood-perfused canine lung lobes from control dogs and dogs with pacing-induced heart failure (paced at 245 beats/min for 4 weeks).
I
Intervention
Thapsigargin (150 nM) or Ca2+ ionophore A-23187 (5-10 microM).
C
Comparator
Control lobes vs. paced (heart failure) lobes.
O
Outcome
Capillary filtration coefficient (Kf,c, an index of microvascular permeability).surrogate

In a canine model of pacing-induced heart failure, altered Ca2+ signaling within the pulmonary microvascular endothelium prevents thapsigargin-induced increases in permeability.

Cite This Study

Ivey et al. (1998) studied this question.

synapsesocial.com/papers/6a75481b99129e9915f57affhttps://doi.org/10.1152/ajpheart.1998.275.3.h844
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rapid ventricular pacing in the dog: pathophysiologic studies of heart failure.1986 · 370 citations
  2. 2Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells.1994 · 207 citations
  3. 3Altered pulmonary microvascular reactivity to norepinephrine in canine pacing-induced heart failure.1994 · 22 citations
  4. 4Angiotensin II‐elicited signal transduction via AT1 receptors in endothelial cells1996 · 82 citations
  5. 5The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells.1993 · 123 citations