Why the study?
Does chronic pacing-induced heart failure alter pulmonary microvascular permeability and the threshold for high-vascular-pressure injury in dogs?
Population
Dogs (n=26 total; 12 paced, 14 control)
Comparison
Chronic pacing at 245 beats per minute for ≈4… vs Unpaced control dogs (n=14)
Design
Preclinical
Follow-up
≈7 weeks
Authors
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May raise edema threshold via remodeling in canine HF models; leaves open translation to human pulmonary protection.
Does chronic pacing-induced heart failure alter pulmonary microvascular permeability and the threshold for high-vascular-pressure injury in dogs?
Vascular remodeling in pacing-induced heart failure confers a modest but important increase in the resistance of lungs to high-vascular-pressure injury and the development of alveolar edema.
Townsley et al. (1995) studied this question.