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QTc prolongation was associated with an increased risk of all-cause mortality among patients with end-stage renal disease undergoing dialysis.
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This commentary highlights that while QTc prolongation is associated with mortality and adverse cardiovascular outcomes in dialysis patients, prospective studies incorporating non-dialysis comparison groups, serial QTc measurements, electrolyte dynamics, and structural cardiac parameters are needed to refine cardiovascular risk prediction.
Cardiovascular Implications of QTc Prolongation in Dialysis. QT prolongation is associated with increased mortality in both dialysis patients and the general population, although its comparative prognostic significance remains uncertain. Serial QTc assessment, consideration of dialysis-related electrolyte changes, and structural cardiac evaluation may improve cardiovascular risk stratification in patients undergoing dialysis.
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Mısgınova et al. (2026) conducted a letter in End-stage renal disease (ESRD) undergoing dialysis. QTc prolongation vs. Normal QTc interval was evaluated on All-cause mortality (HR 1.67, 95% CI 1.56-1.79). QTc prolongation was associated with an increased risk of all-cause mortality among patients with end-stage renal disease undergoing dialysis.
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