Key result
Female sex linked to ~2.4-fold higher risk of severe QTc prolongation in hemodialysis patients.
Why the study?
QTc interval prolongation is an important risk factor for fatal arrhythmias and sudden cardiac death, and identifying associated clinical factors in hemodialysis patients may help prevent cardiovascular complications.
Are clinical factors such as gender, age, and comorbidities associated with QTc interval prolongation in hemodialysis patients?
Cross-Sectional (n=189)
No
Are clinical factors such as gender, age, and comorbidities associated with QTc interval prolongation in hemodialysis patients?
Odds Ratio: 2.4 (95% CI 1.15–4.99)
Absolute Event Rate: 28.57% vs 14.29%
p-value: p=0.02
Female patients on maintenance hemodialysis are at a significantly higher risk for dangerous QTc prolongation compared to males, emphasizing the need for targeted electrocardiographic monitoring in this group.
Female sex associated with QTc prolongation in HD patients; hypothesis-generating and should not yet change practice.
QTc interval prolongation is an important risk factor for fatal arrhythmias and sudden cardiac death. Identifying factors associated with QTc prolongation may help prevent cardiovascular complications. This study aimed to analyze clinical factors associated with the risk of QTc prolongation in hemodialysis patients. This study was conducted with a cross-sectional approach. Bivariate logistic regression analysis was performed to analyze the association of sex, age, body mass index (BMI), and comorbidities (diabetes mellitus, hypertension, heart failure, pneumonia, anemia, and hyperkalemia) with QTc prolongation. 189 subjects were enrolled and divided into two groups based on QTc duration ≥500 ms ( n =41) and <500 ms ( n =148). Of all variables, gender showed a significant association with QTc prolongation (p=0.02; prevalence odds ratio (POR)=2.40; 95% CI: 1.15-4.99), with women having a higher risk of QTc interval ≥500 ms than men. Risk factors such as age >60 years, BMI, diabetes mellitus, hypertension, heart failure, pneumonia, anemia, and hyperkalemia did not show a significant association (p>0.05). These findings support the need for routine ECG monitoring, especially in female patients, to prevent arrhythmias and cardiovascular mortality.
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Nur’amin et al. (2026) conducted a cross-sectional in QTc interval prolongation in maintenance hemodialysis (n=189). Female gender vs. Male gender was evaluated on QTc interval prolongation (≥500 ms) (POR 2.40, 95% CI 1.15-4.99, p=0.02). Female gender was significantly associated with a higher risk of QTc interval prolongation (≥500 ms) in hemodialysis patients compared to men (POR 2.40).
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