Why the study?
Does high flow perfusion (full vascular recruitment) decrease evidence of lung injury compared to low flow perfusion in isolated canine lung lobes?
Population
Isolated lung lobes obtained from 36 mongrel dogs of either gender.
Comparison
High flow perfusion after lung injury induced by… vs Low flow perfusion after lung injury induced by…
Design
Preclinical
Authors
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High-flow perfusion may unmask or exacerbate endothelial injury in isolated lungs; leaves open optimal rates for clinical lung protection.
Does high flow perfusion (full vascular recruitment) decrease evidence of lung injury compared to low flow perfusion in isolated canine lung lobes?
In an isolated canine lung model, increasing blood flow three-fold recruited injured vessels and/or increased vascular injury, with endothelial ectoenzyme activity serving as an earlier indicator of injury than permeability.
Ehrhart et al. (1999) studied this question.
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