Population
Swine carotid medial tissues loaded with fura-2
Comparison
Forskolin or nitroglycerin vs Histamine stimulation or high KCl depolarization…
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for dual cyclic nucleotide mechanisms in arterial relaxation.
Cyclic nucleotides induce arterial smooth muscle relaxation through dual mechanisms involving both reduction of calcium influx and uncoupling of force from intracellular calcium levels.
Chen et al. (1992) studied this question.
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