Population
Histamine-stimulated swine carotid arteries
Design
Preclinical
Authors
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Animal data suggest dual nitrovasodilator mechanisms; leaves open translation to human vascular disease and therapy.
Nitrovasodilators induce arterial relaxation through both reduction in intracellular calcium and uncoupling of stress from myosin phosphorylation.
McDaniel et al. (1992) studied this question.
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