Key result
Nitroglycerin relaxes precontracted rat tail artery primarily by decreasing the intracellular Ca2+ sensitivity of force and partially by repolarization.
Population
Deendothelialized rat tail artery
Design
Preclinical
Authors
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Findings in rat arteries suggest Ca2+ desensitization as key to nitroglycerin action; leaves open applicability to clinical vasodilation.
Nitroglycerin induces arterial relaxation primarily by decreasing intracellular calcium sensitivity of force rather than by inactivating calcium channels or enhancing calcium efflux.
Chen et al. (1996) studied this question. Nitroglycerin was evaluated on Mechanism of relaxation (membrane potential, [Ca2+]i, isometric force). Nitroglycerin relaxes precontracted rat tail artery primarily by decreasing the intracellular Ca2+ sensitivity of force and partially by repolarization.
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