Population
Intact, deendothelialized rat tail artery
Design
Preclinical
Authors
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Should not alter phenylephrine use in humans; leaves open whether all four mechanisms operate in human arteries.
Phenylephrine induces contraction in rat tail arteries through multiple electromechanical and pharmacomechanical mechanisms, primarily depolarization and increased calcium sensitivity.
Chen et al. (1995) studied this question.
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