Population
Rat tail artery segments loaded with the [Ca2+]i-sensitive, intracellular dye fura-2
Comparison
Nitric oxide vs Control conditions (absence of NO)
Design
Preclinical
Authors
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Hypothesis-generating for post-Ca2+ NO vasodilation in animals; human studies required before any clinical consideration.
Nitric oxide induces vasodilation through a mechanism downstream of intracellular calcium mobilization, rather than by decreasing intracellular calcium concentrations.
Tran et al. (1998) studied this question.
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