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January 1, 1991Journal of Cardiovascular Pharmacology

Modulation of Norepinephrine-Induced Vasoconstriction by Endothelin-1 and Nitric Oxide in Rat Tail Artery

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Population

Rat isolated perfused tail artery preparations (endothelium-denuded and endothelium-intact)

Comparison

Endothelin-1 or NG-nitro-L-arginine vs Control responses (baseline without intervention)

Design

Preclinical

Follow-up

Up to 60 minutes

Authors

JRJulianne J. ReidRMIT UniversityPVPhuong A. VoUniversity of LondonALAn T. LieuThe University of Melbourne

Discussion

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Overview

Should not change clinical practice; hypothesis-generating for endothelium-derived factors in vascular tone.

Structured PICO

P
Population
Rat isolated perfused tail artery preparations (endothelium-denuded and endothelium-intact)
I
Intervention
Endothelin-1 (0.3 nM) or NG-nitro-L-arginine (NOLA, 10 microM)
C
Comparator
Control responses (baseline without intervention)
O
Outcome
Vasoconstrictor responses to nerve stimulation and norepinephrinesurrogate

Endothelin-1 and nitric oxide modulate norepinephrine-induced vasoconstriction in rat tail arteries, suggesting an endothelium-derived vasoconstriction-enhancing factor accumulates in perfusion fluid.

Cite This Study

Reid et al. (1991) studied this question.

synapsesocial.com/papers/6a8bd1192ff0ab4f91e95bfchttps://doi.org/10.1097/00005344-199100177-00077
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation by the endothelium of sympathetic vasoconstriction in anin vitropreparation of the rat tail artery1994 · 47 citations
  2. 2The role of nitric oxide in the regional vasodilator effects of endothelin‐1 in the rat1992 · 34 citations
  3. 3Attenuation of vasoconstriction by endogenous nitric oxide in rat caudal artery1992 · 58 citations
  4. 4Interactions Between Nitric Oxide and Endothelin in the Regulation of Vascular Tone of Human Resistance Vessels In Vivo2000 · 162 citations
  5. 5Mechanisms Of Endothelin‐1‐Induced Potentiation Of Noradrenaline Response In Rat Mesenteric Artery2001 · 16 citations