January 1, 1998Journal of Cardiovascular Pharmacology

Endothelin-1 Enhances Pressor Responses to Norepinephrine: Involvement of Endothelin-B Receptor

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Population

Perfused mesenteric arteries from normotensive and DOCA-salt hypertensive rats

Comparison

Perfusion with a subpressor dose of endothelin-1… vs Baseline responses or normotensive rats

Design

Preclinical

Authors

SKSatomi KitaJikei University School of Medicine YTYuko Taguchi YMYasuo MatsumuraAmerican Pharmacists Association

Discussion

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Implication

ETB antagonism merits exploration in salt-sensitive hypertension; leaves open clinical translation from rodent models.

Structured PICO

Population

Perfused mesenteric arteries from normotensive and DOCA-salt hypertensive rats

Intervention

Perfusion with a subpressor dose of endothelin-1 (ET-1) (3 x 10(-10) M) for 15 min, with or without ET receptor antagonists BQ788 (10(-6) M) or FR139317 (10(-6) M)

Comparator

Baseline responses or normotensive rats

Outcome

Pressor responses to norepinephrine (NE)surrogate

Endothelin-1 enhances contractile responses to norepinephrine via ETB receptors, suggesting a mechanism for the maintenance of hypertension in DOCA-salt models.

Cite This Study

Kita et al. (1998) studied this question.

synapsesocial.com/papers/6a86b03f740e6cf4b5cf7afa https://doi.org/10.1097/00005344-199800001-00036

Topics

Hypertension management

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Endothelin-1 Enhances Pressor Responses to Norepinephrine: Involvement of Endothelin-B Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Endothelin-1 Enhances Pressor Responses to Norepinephrine: Involvement of Endothelin-B Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider