June 1, 1992AJP Heart and Circulatory Physiology

Effects of endothelin on resistance arteries of DOCA-salt hypertensive rats

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Population

Resistance arteries from the mesenteric circulation of deoxycorticosterone acetate-salt hypertensive rats…

Comparison

Endothelin-1 exposure vs Uninephrectomized control rats

Design

Preclinical

Authors

LDLi-Yuan DengMedical Council of Canada ESErnesto L. SchiffrinMedical Council of Canada

Discussion

Member takes

Implication

Indicates early remodeling preserves pressure generation in hypertensive rat vessels; hypothesis-generating for human vascular adaptations.

Structured PICO

Population

Resistance arteries (<300 microns lumen diameter) from the mesenteric circulation of deoxycorticosterone acetate (DOCA)-salt hypertensive rats (within 2 weeks of developing hypertension) and uninephrectomized controls

Intervention

Endothelin-1 (ET-1) exposure (with and without endothelium removal)

Comparator

Uninephrectomized control rats

Outcome

Vascular reactivity (active wall tension, media stress, active pressure) and morphological changessurrogate

Small resistance arteries in DOCA-salt hypertensive rats undergo significant morphological changes and exhibit blunted reactivity to ET-1 within 2 weeks of developing hypertension.

Cite This Study

Deng et al. (1992) studied this question.

synapsesocial.com/papers/6a796d9714b028facf0dc3e2 https://doi.org/10.1152/ajpheart.1992.262.6.h1782

Topics

Hypertension management

View Full Paper

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Implication

Indicates early remodeling preserves pressure generation in hypertensive rat vessels; hypothesis-generating for human vascular adaptations.

Effects of endothelin on resistance arteries of DOCA-salt hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of endothelin on resistance arteries of DOCA-salt hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider