Population
Sprague-Dawley (SD) rats and spontaneously hypertensive rats (SHR), including DOCA-salt hypertensive models
Comparison
DOCA-salt treatment; Bosentan in a subset vs DOCA alone, salt alone, or untreated SHR/SD rats
Design
Preclinical
Authors
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ET-1 may drive vascular hypertrophy independently of BP in rat models; leaves open translation to human hypertension.
Vascular overexpression of the endothelin-1 gene induced by DOCA-salt may produce vascular hypertrophy independently of blood pressure elevation.
Schiffrin et al. (1995) studied this question.
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