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August 1, 1996Journal of the American Society of Nephrology

Localization of sites of enhanced expression of endothelin-1 in the kidney of DOCA-salt hypertensive rats.

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Authors

LDLi-Yuan DengRDRobert DayESErnesto L. Schiffrin

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Overview

Endothelin-1 remains an unproven target in hypertension; this preclinical finding leaves open its mechanistic role in renal disease.

Key Points

  • To identify the specific anatomical sites of increased endothelin-1 gene expression in the kidneys of DOCA-salt hypertensive rats.
  • Assessed endothelin-1 mRNA expression in the remaining kidney of DOCA-salt hypertensive rats compared to unilaterally nephrectomized control rats.
  • Performed in situ hybridization histochemistry using a high specific activity 35S-labeled complementary RNA probe.
  • Significant increases in endothelin-1 mRNA transcript abundance were detected in the endothelium of renal blood vessels.
  • Expression was markedly elevated within capillary endothelial cells and mesangial cells of the renal glomeruli.

Cite This Study

Deng et al. (1996) studied this question.

synapsesocial.com/papers/6a830a7ec0477142e551a9d3https://doi.org/10.1681/asn.v781158
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