February 1, 1992Hypertension

Endothelin vascular receptors and responses in deoxycorticosterone acetate-salt hypertensive rats.

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Population

Deoxycorticosterone acetate-salt hypertensive rats and uninephrectomized control rats

Comparison

Endothelin-1 exposure to blood vessels vs Uninephrectomized control rats

Design

Preclinical

Authors

PNPaul NguyenCamden and Campbelltown Hospitals APAngèle ParentUniversity of Chicago LDLi-Yuan DengMedical Council of Canada

Discussion

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Implication

Supports endothelin receptor regulation studies in hypertension models; leaves open clinical relevance in humans.

Structured PICO

Population

Deoxycorticosterone acetate (DOCA)-salt hypertensive rats (within 2 weeks of development of hypertension) and uninephrectomized control rats

Intervention

Endothelin-1 (ET-1) exposure to blood vessels (thoracic aorta and mesenteric artery rings)

Comparator

Uninephrectomized control rats

Outcome

Vasoconstrictor effect, binding of ET-1, and response of inositol phosphates to ET-1surrogate

Decreased density of ET-1 receptors in DOCA-salt hypertensive rats leads to reduced activation of phospholipase C and reduced ET-1-induced vasoconstriction, likely due to receptor downregulation.

Cite This Study

Nguyen et al. (1992) studied this question.

synapsesocial.com/papers/6a6fafe635aa2c282ce106a4 https://doi.org/10.1161/01.hyp.19.2_suppl.ii98

Topics

Hypertension management

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Endothelin vascular receptors and responses in deoxycorticosterone acetate-salt hypertensive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Endothelin vascular receptors and responses in deoxycorticosterone acetate-salt hypertensive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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