Population
Normotensive Wistar-Kyoto rats and 12-week-old spontaneously hypertensive rats anesthetized with urethane…
Comparison
Intravenous injection of endothelin vs Intravenous injection of angiotensin II…
Design
Preclinical
Authors
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May guide preclinical hypertension studies; leaves open human translation and clinical relevance.
Endothelin produces a unique, potent, and long-lasting pressor response that is partially mediated by calcium channels and is exaggerated in spontaneously hypertensive rats.
Miyauchi et al. (1989) studied this question.
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