Why the study?
Does bosentan pretreatment alter the hemodynamic responses to angiotensin II in normotensive and hypertensive rats?
Population
Conscious, unrestrained normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR)
Comparison
Pretreatment with bosentan followed by… vs Intravenous infusions of angiotensin II before…
Design
Preclinical
Authors
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Hypothesis-generating for endothelin modulation of Ang II effects in hypertension; leaves open human translation.
Does bosentan pretreatment alter the hemodynamic responses to angiotensin II in normotensive and hypertensive rats?
Endothelin contributes to the hemodynamic effects of Angiotensin II, particularly in spontaneously hypertensive rats, suggesting a role in exaggerated pressor responsiveness.
Balakrishnan et al. (1996) studied this question.
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