Why the study?
Does bosentan prevent or treat hypertension and cardiac hypertrophy in rats with angiotensin II-induced hypertension?
Population
Rats with hypertension induced by angiotensin II infusion (200 ng/kg per min, s.c., osmotic pump for 17 days)
Comparison
Bosentan administered either as prevention or… vs Untreated rats receiving angiotensin II infusion…
Design
Preclinical
Follow-up
17 days
Authors
Loading...
No clinical implications for hypertension therapy; leaves open endothelin mediation in angiotensin II models.
Does bosentan prevent or treat hypertension and cardiac hypertrophy in rats with angiotensin II-induced hypertension?
Endogenous endothelin participates in the initial phase of angiotensin II-induced hypertension and acts as a local mediator of cardiac hypertrophy independent of blood pressure levels.
Ficai et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: