September 1, 1989AJP Heart and Circulatory Physiology

Regional hemodynamic and baroreflex effects of endothelin in rats

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Population

Conscious, freely moving rats and chloralose-anesthetized rats

Comparison

Endothelin with or without various… vs Phenylephrine

Design

Preclinical

Authors

MKMark M. KnuepferSaint Louis University Hospital SHShuping HanNanjing Children's Hospital ATAngelo J. TrapaniNovartis (United States)

Discussion

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Implication

Delineates regional endothelin vasoconstriction independent of baroreflex in rats; leaves open clinical translation.

Structured PICO

Population

Conscious, freely moving rats and chloralose-anesthetized rats

Intervention

Endothelin (0.67 nmol/kg) with or without various pharmacological blockers (nifedipine, pentolinium, atropine methyl sulfate, vasopressin V1 antagonist, indomethacin, verapamil)

Comparator

Phenylephrine (for baroreflex function curve comparison)

Outcome

Regional hemodynamics (pressor response, bradycardia, hindquarter and mesenteric vasoconstriction) and baroreflex sensitivity (renal sympathetic nerve activity)surrogate

Endothelin acts as a potent vasoconstrictor with distinct regional mechanisms but does not alter baroreflex control of sympathetic nerve activity or heart rate in rats.

Cite This Study

Knuepfer et al. (1989) studied this question.

synapsesocial.com/papers/6a980768cfa25b768ec6355e https://doi.org/10.1152/ajpheart.1989.257.3.h918

View Full Paper

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Regional hemodynamic and baroreflex effects of endothelin in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regional hemodynamic and baroreflex effects of endothelin in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider