Why the study?
Does intravenous endothelin alter regional hemodynamics and renal function in awake normotensive rats?
Population
Awake normotensive rats
Comparison
Intravenous injection of endothelin, with or… vs Basal levels (pre-treatment)
Design
Preclinical
Follow-up
Short-term (up to 10 minutes reported in abstract)
Authors
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Endothelin effects in awake rats warrant caution in human extrapolation; extends preclinical models of biphasic vascular responses.
Does intravenous endothelin alter regional hemodynamics and renal function in awake normotensive rats?
Endothelin produces a biphasic hemodynamic response in awake rats, characterized by transient hypotension followed by sustained hypertension mediated by increased vascular resistance.
Madeddu et al. (1989) studied this question.
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