Key result
Pretreatment with endothelin-A receptor antagonist BQ-123 completely inhibited the hypotensive phase, reduced the subsequent rise in blood pressure by 83%, and prevented mortality evoked by endothelin-1.
Why the study?
Does endothelin-1 modulate cardiovascular and respiratory function in the ventrolateral medulla of normotensive rats?
Population
Urethane-anesthetized normotensive rats
Comparison
Microinjection of endothelin-1 into the rostral… vs Saline pretreatment
Design
Preclinical
Authors
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Endothelin-A blockade blunts ET-1 effects in rat medulla; hypothesis-generating and should not yet inform human therapy.
Does endothelin-1 modulate cardiovascular and respiratory function in the ventrolateral medulla of normotensive rats?
Endothelin-1 modulates cardiovascular and respiratory function in the ventral medulla of normotensive rats, and its effects can be blocked by endothelin-A receptor antagonists.
Mosqueda‐Garcia et al. (1995) studied Normotensive. Endothelin-1 and Endothelin-A receptor antagonists (BQ-123) vs. Saline was evaluated on Blood pressure, heart rate, respiratory frequency, and mortality. Pretreatment with endothelin-A receptor antagonist BQ-123 completely inhibited the hypotensive phase, reduced the subsequent rise in blood pressure by 83%, and prevented mortality evoked by endothelin-1.
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