Key result
Endothelin mRNA is localized in close proximity to ET binding sites in many organs, suggesting that ET may serve in several tissues as a neuromodulator or local hormone.
Population
Rat tissues (19-day rat fetus and adult) and microvascular endothelial cells in culture
Design
Preclinical
Authors
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Suggests paracrine endothelin roles merit functional study; leaves open any clinical relevance or therapeutic targeting.
Endothelin mRNA is synthesized locally in several tissues in close proximity to its binding sites, suggesting it acts as a neuromodulator or local hormone.
MacCumber et al. (1989) studied this question. In situ hybridization and Northern blot analysis was evaluated on Localization of ET mRNA in rat tissues. Endothelin mRNA is localized in close proximity to ET binding sites in many organs, suggesting that ET may serve in several tissues as a neuromodulator or local hormone.
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