May 1, 1990Journal of Clinical InvestigationOpen Access

Endothelin-1 mRNA is widely expressed in porcine and human tissues.

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: ET-1 mRNA expression analysis. Primary outcome: Detection and localization of ET-1 mRNA.

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Key result

Endothelin-1 mRNA is widely transcribed in human and porcine tissues, including heart, kidney, adrenal, and lung, with localized expression in renal blood vessels.

Authors

DNDerek J. NunezCasma Therapeutics (United States)MBMorris J. BrownPreventive Cardiology ADAnthony P. DavenportVascular Medicine

Discussion

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Implication

Broad ET-1 transcription suggests multi-organ roles; leaves open functional validation and clinical translation.

PICO

Population

Basic science study examining ET-1 mRNA expression in porcine tissues and human cardiac, lung, and umbilical vein endothelial cells.

Exposure / Comparator

ET-1 mRNA expression analysis

Primary Outcome

Detection and localization of ET-1 mRNA

Limitations

Failure to visualize ET-1 mRNA in capillaries may reflect absence of expression or insufficient sensitivity of the in situ hybridization technique.
Confirmation of the cellular site of expression requires microautoradiographic study, which is hindered by the small size of the radioactive signal.

Cite This Study

Nunez et al. (1990) studied this question. ET-1 mRNA expression analysis was evaluated on Detection and localization of ET-1 mRNA. Endothelin-1 mRNA is widely transcribed in human and porcine tissues, including heart, kidney, adrenal, and lung, with localized expression in renal blood vessels.

synapsesocial.com/papers/6a64e1b41fe8a3b7faf6970b https://doi.org/10.1172/jci114601

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Endothelin-1 mRNA is widely expressed in porcine and human tissues.

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

Endothelin-1 mRNA is widely expressed in porcine and human tissues.

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

Also Consider

Also Consider