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April 1, 1992Endocrinology

Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors.

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Population

Rat lung cDNA library and rat tissues

Design

Preclinical

Authors

SHSeiji HoriJikei University School of MedicineYKYasato KomatsuKoshien UniversityRSRyuichi ShigemotoInstitute of Science and Technology Austria

Discussion

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Implication

No immediate clinical translation from rat mapping; leaves open human validation of ETA/ETB targeting.

Structured PICO

P
Population
Rat lung cDNA library and rat tissues
I
Intervention
Isolation of cDNA clones and in situ/blot hybridization analyses
O
Outcome
Tissue distribution and cellular localization of ETA and ETB mRNAssurrogate

The study demonstrates distinct tissue distribution patterns for ETA and ETB receptor mRNAs in rats, indicating that ETA plays a primary role in endothelin-induced vascular contraction.

Cite This Study

Hori et al. (1992) studied this question.

synapsesocial.com/papers/6a23bd859e1c90a91c092c00https://doi.org/10.1210/endo.130.4.1312429
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.1988 · 550 citations
  2. 2Cloning and expression of human endothelin‐1 receptor cDNA1991 · 284 citations
  3. 3Sarafotoxin, a Novel Vasoconstrictor Peptide: Phosphoinositide Hydrolysis in Rat Heart and Brain1988 · 368 citations
  4. 4MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS1991 · 1,370 citations
  5. 5Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.1991 · 358 citations