Key result
ET(A) and ET(B) receptors are differentially distributed in the vascular and tubular systems of the rat kidney, supporting their cooperative role in cortical vasoconstriction.
Population
Rat kidney model
Design
Preclinical
Authors
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Remains preclinical; should not guide ET antagonist use and leaves open human renal vasoconstriction relevance.
The distinct distribution of ET(A) and ET(B) receptors in the rat kidney supports their cooperative role in renal cortical vasoconstriction and differential effects on medullary function.
Wendel et al. (2006) studied this question. Immunofluorescence microscopy for ET(A) and ET(B) receptors was evaluated on Cellular localization of ET(A) and ET(B) receptors in the vascular and tubular system of the rat kidney. ET(A) and ET(B) receptors are differentially distributed in the vascular and tubular systems of the rat kidney, supporting their cooperative role in cortical vasoconstriction.
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