Key result
ETB receptors develop postnatally in a time- and tissue-specific manner, appearing mainly on arterial smooth muscle cells starting at day 5 in small coronary and meningeal arteries.
Population
Rats (postnatal day 0 through day 28, and adult)
Design
Preclinical
Authors
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ETB receptor mapping in rat vessels; leaves open any role in human vascular maturation or tone disorders.
The study demonstrates that vasoconstrictor ETB receptors in rats develop postnatally in a highly tissue-specific and age-dependent manner, primarily on arterial smooth muscle cells.
Wendel et al. (2005) studied this question. Postnatal development was evaluated on Distribution of ETB receptors in different vascular beds. ETB receptors develop postnatally in a time- and tissue-specific manner, appearing mainly on arterial smooth muscle cells starting at day 5 in small coronary and meningeal arteries.
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