July 1, 1996Clinical and Experimental Pharmacology and Physiology

Cellular Localization of Endothelin Receptor Subtypes in the Rat Kidney Following in Vitro Labelling

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Population

Rat kidney tissue

Design

Preclinical

Authors

RDRachael DeanQuadram Institute JZJia L. ZhuoTulane University DADaine AlcornThe University of Melbourne

Discussion

Member takes

Implication

ET receptor mapping in rat kidney does not yet inform human therapies; leaves open subtype-specific functional roles in renal disease.

Structured PICO

Population

Rat kidney tissue

Intervention

In vitro labelling with [125I]-endothelin and ET receptor subtype selective ligands (sarafotoxin 6c and BQ123)

Outcome

Cellular localization of ETA and ETB receptor subtypessurrogate

In the rat kidney, ETB receptors are predominantly localized to the fenestrated endothelium of capillaries, whereas both ETA and ETB receptors are present in renomedullary interstitial cells.

Cite This Study

Dean et al. (1996) studied this question.

synapsesocial.com/papers/6a953ba1d33c5efb307cfbc3 https://doi.org/10.1111/j.1440-1681.1996.tb02773.x

View Full Paper

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Bookmark

Cellular Localization of Endothelin Receptor Subtypes in the Rat Kidney Following in Vitro Labelling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cellular Localization of Endothelin Receptor Subtypes in the Rat Kidney Following in Vitro Labelling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider