Key result
Endothelin-1 demonstrated specific, high-affinity binding to rat renal glomeruli (dissociation constant 8.3 nM) and stimulated prostaglandin E2 production.
Population
Isolated rat renal glomeruli
Design
Preclinical
Authors
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Hypothesis-generating for ET-1 in glomerular regulation; leaves open translation to human renal disease or therapy.
Demonstrates the presence of high-affinity ET-1 receptors in rat renal glomeruli that stimulate PGE2 production, suggesting a role in regulating glomerular function.
Orita et al. (1989) studied this question. Endothelin-1 (ET-1) was evaluated on Specific binding of [125I]ET-1 to glomeruli and PGE2 production. Endothelin-1 demonstrated specific, high-affinity binding to rat renal glomeruli (dissociation constant 8.3 nM) and stimulated prostaglandin E2 production.
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