Key result
Intracisternal administration of endothelins at doses that do not change resting MAP or HR significantly increased baroreflex sensitivity, selectively affecting the vagal component.
Population
Conscious normotensive rats
Comparison
Intracisternal administration of ET-1, ET-2, or… vs Intravenous administration (for ET-1) or baseline
Design
Preclinical
Authors
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Hypothesis-generating in rats; leaves open translation of central endothelin baroreflex effects to human cardiovascular disease.
Centrally administered endothelins sensitize the baroreceptor heart rate reflex in conscious rats without altering resting blood pressure or heart rate.
Itoh et al. (1991) studied Conscious normotensive rats. Centrally administered endothelins (ET-1, ET-2, ET-3) vs. Intravenous ET-1 or baseline was evaluated on Baroreflex sensitivity. Intracisternal administration of endothelins at doses that do not change resting MAP or HR significantly increased baroreflex sensitivity, selectively affecting the vagal component.
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