Why the study?
Does Endothelin-1 induce vasoconstriction and release of atrial natriuretic peptides in rats?
Population
Male Sprague-Dawley rats (awake and anaesthetized)
Comparison
Endothelin-1 i.v. bolus injections vs Baseline and co-administration with verapamil…
Design
Preclinical
Authors
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ET-1 vascular and ANP effects in rats should not change practice; leaves open direct stimulation independent of hemodynamics in human disease.
Does Endothelin-1 induce vasoconstriction and release of atrial natriuretic peptides in rats?
Endothelin-1 induces biphasic blood pressure changes and directly stimulates ANP release from atrial myocytes independent of hemodynamics.
Öhman et al. (1990) studied this question.
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