Key result
Low doses of endothelin-1 (e.g., 10^-11 M or 1 pmol/kg.min) significantly decreased atrial natriuretic peptide secretion in rat models, whereas high doses stimulated secretion.
Population
Isolated perfused rat hearts and conscious unrestrained rats
Design
Preclinical
Authors
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Animal data on biphasic ET-1 effects on ANP are hypothesis-generating; human studies needed before any clinical consideration.
Low doses of endothelin-1 exert a short-acting inhibitory effect on ANP secretion from the heart, likely mediated by prostanoids, contrasting with the stimulatory effect of high doses.
Shirakami et al. (1993) studied this question. Endothelin-1 (ET-1) was evaluated on Atrial natriuretic peptide (ANP) secretion. Low doses of endothelin-1 (e.g., 10^-11 M or 1 pmol/kg.min) significantly decreased atrial natriuretic peptide secretion in rat models, whereas high doses stimulated secretion.
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