Population
Chronically-instrumented conscious Long Evans rats (n=11 total; n=4 for 0.05 nmol/kg and n=7 for 0.5 nmol/kg)
Comparison
Intravenous and intraarterial injections of… vs Comparison between i.v. and i.a. routes of…
Design
Preclinical
Follow-up
30 minutes
Authors
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Questions pulmonary ET-1 handling in rats; leaves open whether local conversion drives human vascular effects.
The similar haemodynamic responses to intravenous and intraarterial administration suggest that local, rather than systemic, conversion of exogenous big ET-1 to ET-1 drives its regional haemodynamic actions.
Gardiner et al. (1993) studied this question.
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