What is the clinical evidence from this study?

Study design: Other. Intervention: ET(B) receptor blockade (BQ-788) vs. Control. Primary outcome: Pressor response to big ET-1 and big ET-2.

What does this research mean for the field?

ET(B) receptor blockade potentiates the pressor response to big endothelin-1, but not to big endothelin-2, in anesthetized rabbits. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 2000Hypertension

ET B Receptor Blockade Potentiates the Pressor Response to Big Endothelin-1 But Not Big Endothelin-2 in the Anesthetized Rabbit

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Key result

ET(B) receptor blockade sharply potentiates pressor responses to ET-1, ET-2, and big ET-1 in rabbits.

Why the study?

Does ET(B) receptor blockade modulate the pressor response to big ET-1 and big ET-2 in anesthetized rabbits?

Population

Anesthetized rabbits

Comparison

ET receptor blockade with BQ-788, ET receptor… vs Control animals (no blockade)

Design

Preclinical

Authors

JGJean‐Philippe GrattonVascular / Pulmonary Vascular GRGiles A. RaeUniversidade Federal de Santa Catarina GBGhassan BkailyUniversité de Sherbrooke

Discussion

Member takes

Implication

ET(B) blockade may enhance pressor effects of select endothelins in rabbits; leaves open translation to human hypertension.

Structured PICO

Does ET(B) receptor blockade modulate the pressor response to big ET-1 and big ET-2 in anesthetized rabbits?

Population

Anesthetized rabbits

Intervention

ET(B) receptor blockade with BQ-788 (0.25 mg/kg), ET(A) receptor blockade with BQ-123 (1 mg/kg), or indomethacin (10 mg/kg) prior to injection of ET-1, ET-2, big ET-1, or big ET-2

Comparator

Control animals (no blockade)

Outcome

Pressor responses (hemodynamic properties)surrogate

ET(B) receptors play a significant limiting role on pressor responses to big ET-1, but do not modulate the hemodynamic properties of the ET-2 precursor in anesthetized rabbits.

Cite This Study

Gratton et al. (2000) studied this question. ET(B) receptor blockade (BQ-788) vs. Control was evaluated on Pressor response to big ET-1 and big ET-2. Blockade of ET(B) receptors with BQ-788 sharply potentiated the pressor responses to ET-1, ET-2, and big ET-1, but not to big ET-2 in anesthetized rabbits.

synapsesocial.com/papers/6aa744cf18213e0978353bf2 https://doi.org/10.1161/01.hyp.35.3.726

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ET B Receptor Blockade Potentiates the Pressor Response to Big Endothelin-1 But Not Big Endothelin-2 in the Anesthetized Rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ET B Receptor Blockade Potentiates the Pressor Response to Big Endothelin-1 But Not Big Endothelin-2 in the Anesthetized Rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider