Key result
In the anesthetized rabbit, ET-1 and ET-3 produced modest pulmonary vasoconstriction and marked systemic vasodilation, acting differently in the systemic and pulmonary vascular beds.
Population
Anesthetized intact-chest rabbits
Design
Preclinical
Authors
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Animal findings on ET differential effects should not guide therapy; leaves open translational relevance to human vascular beds.
In the rabbit model, ET-1 and ET-3 demonstrate potent systemic vasodilator activity alongside modest pulmonary vasoconstriction, indicating differential effects in systemic versus pulmonary vascular beds.
Lippton et al. (1991) studied this question. Endothelin-1 and Endothelin-3 was evaluated on Pulmonary and systemic vascular responses. In the anesthetized rabbit, ET-1 and ET-3 produced modest pulmonary vasoconstriction and marked systemic vasodilation, acting differently in the systemic and pulmonary vascular beds.
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