January 1, 1994Acta Physiologica Scandinavica
In vivo effects of endothelin‐2, endothelin‐3 and ETAreceptor blockade on arterial, venous and capillary functions in cat skeletal muscle
Key result
Infusion of endothelin-2 and endothelin-3 caused an average increase in total regional vascular resistance of 80% and 35%, respectively, which was abolished by ETA receptor antagonist FR 139317.
Population
Cat gastrocnemius muscle in vivo
Design
Preclinical
Follow-up
20 min infusion
Authors
Discussion
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Member takes
Implication
ETA receptor blockade abolishes endothelin-2/3 vasoconstriction in animal models; leaves open translation to human vascular regulation.
Structured PICO
P
Population
Cat gastrocnemius muscle in vivo
I
Intervention
Infusion of endothelin-2 or endothelin-3 (200-1600 ng kg-1 min-1, i.a.) with or without ETA receptor antagonist FR 139317
O
Outcome
Vascular tone (resistance) in large-bore arterial resistance vessels, small arterioles, and veins, capillary pressure, and fluid exchangesurrogate
Endothelin-2 and endothelin-3 elicit ETA receptor-mediated vasoconstriction primarily in small arterioles, with endothelin-2 also causing venoconstriction.
Cite This Study
Ulf Ekelund (1994) studied this question. Endothelin-2, endothelin-3, and ETA receptor antagonist FR 139317 was evaluated on Total regional vascular resistance. Infusion of endothelin-2 and endothelin-3 caused an average increase in total regional vascular resistance of 80% and 35%, respectively, which was abolished by ETA receptor antagonist FR 139317.