July 1, 1993Acta Physiologica Scandinavica
In‐vivoeffects of endothelin‐1 and ETareceptor blockade on arterial, venous and capillary functions in skeletal muscle
Key result
Endothelin-1 infusion caused a three-fold increase in total regional vascular resistance, an effect that was fully abolished by the ETA receptor antagonist FR 139317.
Why the study?
Does endothelin-1 and ETA receptor blockade affect vascular tone and capillary fluid exchange in cat skeletal muscle?
Population
Cat gastrocnemius muscle model
Comparison
Endothelin-1 and ETA receptor antagonist FR… vs Basal/resting conditions
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
ETA blockade abolishes ET-1 vasoconstriction in feline muscle; leaves open human translation for vascular tone and edema.
Structured PICO
Does endothelin-1 and ETA receptor blockade affect vascular tone and capillary fluid exchange in cat skeletal muscle?
P
Population
Cat gastrocnemius muscle model
I
Intervention
Endothelin-1 (100-1600 ng kg-1 min-1, i.a.) and ETA receptor antagonist FR 139317 or phosphoramidon
C
Comparator
Basal/resting conditions
O
Outcome
Vascular tone (resistance) in large-bore arterial resistance vessels, small arterioles, and veins, as well as capillary pressure and fluid exchangesurrogate
Endothelin-1 causes profound, long-lasting vasoconstriction preferentially in small arterioles and veins, leading to increased capillary pressure and edema, which is mediated by ETA receptors.
Cite This Study
Ekelund et al. (1993) studied Vascular tone in skeletal muscle (animal model). Endothelin-1 and ETA receptor antagonist FR 139317 was evaluated on Vascular resistance in large-bore arterial resistance vessels, small arterioles, and veins. Endothelin-1 infusion caused a three-fold increase in total regional vascular resistance, an effect that was fully abolished by the ETA receptor antagonist FR 139317.