Key result
Endothelin-1 infusion caused a three-fold increase in total regional vascular resistance, an effect that was fully abolished by the ETA receptor antagonist FR 139317.
Why the study?
Does endothelin-1 and ETA receptor blockade affect vascular tone and capillary fluid exchange in cat skeletal muscle?
Does endothelin-1 and ETA receptor blockade affect vascular tone and capillary fluid exchange in cat skeletal muscle?
Endothelin-1 causes profound, long-lasting vasoconstriction preferentially in small arterioles and veins, leading to increased capillary pressure and edema, which is mediated by ETA receptors.
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ETA blockade abolishes ET-1 vasoconstriction in feline muscle; leaves open human translation for vascular tone and edema.
Ekelund et al. (1993) studied Vascular tone in skeletal muscle (animal model). Endothelin-1 and ETA receptor antagonist FR 139317 was evaluated on Vascular resistance in large-bore arterial resistance vessels, small arterioles, and veins. Endothelin-1 infusion caused a three-fold increase in total regional vascular resistance, an effect that was fully abolished by the ETA receptor antagonist FR 139317.
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